pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of CYP3A4 inducers may possibly lessen sufentanil degrees and efficacy, maybe precipitating withdrawal syndrome in people which have made Bodily dependence to sufentanil. Discontinuation of conc… Read More